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In particular, ER UPR-mediated activation of JNK has been linked to the development of insulin resistance and diabetes by inhibition of insulin receptor signaling (131)

Nat Rev Mol Cell Biol 21(10):607632

Exploring the Quantitative Relationship Between the Level of MDR1 Transcript, Protein and Function Using Digoxin as a Marker of MDR1-Dependent Drug Efflux Activity

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Other studies have indicated that enteroendocrine cells may migrate at a rate 5 times slower than other epithelial cells 105